Our Key Ingredient: Nicotinamide Riboside (NR)
Nicotinamide riboside (NR), is a unique member of the vitamin B3 family and has been found to be naturally occurring in milk in trace amounts . The body converts NR into Nicotinamide Adenine Dinucleotide (NAD+) which is an essential molecule found in every living cell.
NAD+ enables cells to convert the food that we eat into the energy that we need. NAD+ is also the communication molecule between the cell nucleus and the mitochondria which are the energy producing factories in the cell. If NAD+ levels are low, then communication may be impaired and mitochondrial dysfunction may result.
When this occurs, everything begins to break down.
Why is NR better than other forms of vitamin B3?
In 2004, NR emerged as a newly discovered NAD+ (nicotinamide adenine dinucleotide) precursor and has been pre-clinically demonstrated to be superior to both nicotinamide and niacin in increasing NAD+, both of which are standard forms of vitamin B3 commonly used in vitamin supplements and foods [2-4]. This is because NR is not reliant upon a conversion step requiring the enzyme "NAMPT" [7-8]. The activity level of NAMPT determines the amount of nicotinamide that is converted into NAD+, which is why this step is commonly referred to as the "rate limiting step".
As normal ageing occurs, the activity of NAMPT is thought to decrease [10-14]. NR can be used by the cell to make NAD+ without this enzymatic step. Moreover, unlike nicotinic acid, NR does not bind to the receptor responsible for flushing.
- Collagen is the main structural protein that provides strength and elasticity to skin, bones, cartilage and connective tissue. Cell Revival contains type 2 collagen, which can stimulate collagen production and help with joint pain. Our collagen is also hydrolysed, which means it’s more easily absorbed into the body compared to normal collagen.
Orally administered collagen hydrolysate (type 2 collagen) has been shown to be absorbed intestinally and to accumulate in cartilage. Collagen production is stimulated and the density of collagn fibrils and fibroblasts increases.
- Vitamin C
- Vitamin C (ascorbic acid) is a powerful antioxidant for the synthesis of collagen, the structural element that provides for shape and firmness in your skin. Ageing and excessive exposures to UV light or pollutants cause a decline in vitamin C in your body.
Your body cannot generate vitamin C, so you must receive it through supplements and food. Apart from preventing skin ageing symptoms, vitamin C can also enhance your immune system, protecting you from colds and coughs. It also facilitates the absorption of iron, which is an essential component of haemoglobin (a major protein molecule in red blood cells that carries oxygen from your lungs to transport it throughout our body) Vitamin C also has an impressive ability to protect and treat a wide range of diseases, including cancer.
Deficiency symptoms: Fatigue, depression and connective tissue defects (e.g. gingivitis, petechiae, rash, internal bleeding and impaired wound healing).
- What are Antioxidants?
- Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin ageing, which is characterised by wrinkles and atypical pigmentation. UV exposure can enhance ROS generation in cells. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced ageing of the skin.
Antioxidants can protect your body from the harmful effects of free radicals, which are molecules that have an unpaired electron. Because of this unpaired electron, free radicals seek out electrons from other cells, oxidising them and damaging them and the tissues they form. Oxidation caused by free radicals is believed to be a primary cause of age-related degeneration and disease.
- Hyaluronic Acid (HA)
- Hyaluronic acid is a naturally occurring biodegradable polymer with a variety of applications in medicine, including scaffolding for tissue engineering, dermatological fillers and lubrication for joint conditions. HA is available in most connective tissues in body fluids, responsible for several structural properties of tissues, and involved in cellular signaling. A reduction in HA mass or molecular weight via degradation or slowing of synthesis affects physical and chemical properties such as tissue volume, viscosity and elasticity.
HA can be a key player in the activation or suppression of inflammation by participating in the improvement of cell infiltration. HA can bind a large number of water molecules which improves tissue hydration and their resistance to mechanical damage. HA is widely available, fully resorbable, and biocompatible and can also be used as a marker in the diagnosis of certain cancers and liver diseases.